Meta-GRN: Diffusion-Coupled Model of Root Epidermis
This repository contains the implementation of the meta-GRN model described in our 2025 paper (npj Systems Biology and Applications). It simulates how lateral inhibition and protein diffusion (CPC and GL3/EGL3) coordinate cell-fate decisions in the Arabidopsis thaliana root epidermis.
Key Features:
- Hybrid Modeling: Integrates discrete logical rules (GRN) with reaction-diffusion dynamics.
- Mutant Simulations: Includes configurations to replicate wild-type patterns and various mutant phenotypes (cpc, wer, etc.).
- Spatial Analysis: Tools to visualize the interspersed “hair” and “non-hair” cell arrangements.
Technical Stack:
- Language: C