CV

Education

Ph.D. in Biomedical Sciences, National Autonomous University of Mexico (UNAM).
B.Sc. in Biology, National Autonomous University of Mexico (UNAM).
B.Sc. in Control Engineering, National Polytechnic Institute (IPN).

Work Experience

Lecturer | 2021 – 2024

Autonomous University of Mexico City (UACM)

Taught undergraduate courses: Biostatistics, Biochemistry, and Molecular Biology.
Developed pedagogical materials for data analysis in biological contexts.

Research Assistant | 2012 – 2014

Laboratory of Molecular Genetics, Institute of Ecology, UNAM

Focus: Bioinformatics analysis and mathematical modeling of cell cycle gene regulatory networks.
Supervisor: Dr. Elena Álvarez-Buylla Roces.

National Research Assistant (CONACYT) | 2008 – 2010

Molecular Evolution Laboratory, Institute of Ecology, UNAM

Focus: Metagenomics analysis and bioinformatics pipeline development.
Supervisor: Dr. Valeria Souza Saldivar.

Skills

Computational & Mathematical Modeling

Molecular Biology & Biochemistry

Genomics: DNA/RNA extraction, RT-PCR, site-directed mutagenesis, Next-Generation Sequencing (NGS).
Protein Engineering: Bacterial and mammalian protein expression, protein refolding, ELISA.
Chromatography & Purification: FPLC, HPLC (Affinity, Gel Filtration, Ion Exchange, Reverse Phase), SDS-PAGE, Western Blot.
Cell Culture: Transformation, membrane filtration, and dialysis.

Publications

Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback

Castillo-Jiménez, A., Garay-Arroyo, A., Sánchez, M. D. L. P., Martínez-García, J. C., & Álvarez-Buylla, E. R. (2025). Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback. npj Systems Biology and Applications, 11(1), 107.

Extended discrete gene regulatory network model for the Arabidopsis thaliana root-hair cell fate

Castillo-Jiménez, A., Garay-Arroyo, A., de La Paz Sánchez, M., García-Ponce, B., Martínez-García, J. C., & Álvarez-Buylla, E. R. (2023). Extended discrete gene regulatory network model for the Arabidopsis thaliana root-hair cell fate. bioRxiv, 2023-11.

Stochastic Turing patterns of trichomes in Arabidopsis leaves

Di Patti, F., Ugartechea Chirino, Y., Arbel-Goren, R., Sharon, T., Castillo, A., Alvarez–Buylla, E., ... & Stavans, J. (2023). Stochastic Turing patterns of trichomes in Arabidopsis leaves. Proceedings of the National Academy of Sciences, 120(42), e2309616120.

Multi-level gene regulatory network models to understand complex mechanisms underlying plant development

García-Gómez, M. L., Castillo-Jiménez, A., Martínez-García, J. C., & Alvarez-Buylla, E. R. (2020). Multi-level gene regulatory network models to understand complex mechanisms underlying plant development. Current Opinion in Plant Biology, 57, 171-179.

A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle

Ortiz-Gutiérrez, E., García-Cruz, K., Azpeitia, E., Castillo, A., Sánchez, M. D. L. P., & Álvarez-Buylla, E. R. (2015). A dynamic gene regulatory network model that recovers the cyclic behavior of Arabidopsis thaliana cell cycle. PLoS computational biology, 11(9), e1004486.

Talks & Seminars

Cellular patterns in the root epidermis of Arabidopsis thaliana emerge from the dynamic feedback between the gene regulatory network and diffusion.

October 09, 2025

Talk at Institute of Ecology-UNAM, Mexico City, México

Service and Leadership

Scientific Collaboration: Active member of multiple international research networks and computational biology communities.
Technical Community: Participant in various collaborative platforms for systems biology and open-source software development.

Aarón Castillo Jiménez

CV