Aarón Castillo Jiménez

Aarón Castillo Jiménez

I'm a systems biologist working in pattern formation and cell differentiation.

Publications

You can also find my articles on my Google Scholar profile.

Journal Articles

Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback

Published in npj Systems Biology and Applications, 2025

This paper introduces a diffusion-coupled meta-GRN model to explain how spatial cellular patterns emerge from the feedback between genetic networks and molecular diffusion.

Recommended citation: Castillo-Jiménez, A., Garay-Arroyo, A., Sánchez, M. D. L. P., Martínez-García, J. C., & Álvarez-Buylla, E. R. (2025). Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback. npj Systems Biology and Applications, 11(1), 107.
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Extended discrete gene regulatory network model for the Arabidopsis thaliana root-hair cell fate

Published in bioRxiv, 2023

This work presents an updated and expanded discrete model of the gene regulatory network governing root-hair cell fate, incorporating additional regulatory nodes and hormonal signaling pathways.

Recommended citation: Castillo-Jiménez, A., Garay-Arroyo, A., de La Paz Sánchez, M., García-Ponce, B., Martínez-García, J. C., & Álvarez-Buylla, E. R. (2023). Extended discrete gene regulatory network model for the Arabidopsis thaliana root-hair cell fate. bioRxiv, 2023-11.
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Stochastic Turing patterns of trichomes in Arabidopsis leaves

Published in Proceedings of the National Academy of Sciences (PNAS), 2023

This paper combines statistical characterization and theoretical modeling to show that trichome patterns in Arabidopsis are driven by demographic noise, manifesting as stochastic Turing patterns.

Recommended citation: Di Patti, F., Ugartechea Chirino, Y., Arbel-Goren, R., Sharon, T., Castillo, A., Alvarez–Buylla, E., ... & Stavans, J. (2023). Stochastic Turing patterns of trichomes in Arabidopsis leaves. Proceedings of the National Academy of Sciences, 120(42), e2309616120.
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Multi-level gene regulatory network models to understand complex mechanisms underlying plant development

Published in Current Opinion in Plant Biology, 2020

This review discusses the integration of gene regulatory networks with physicochemical fields through multi-level modeling to understand plant morphogenesis.

Recommended citation: García-Gómez, M. L., Castillo-Jiménez, A., Martínez-García, J. C., & Alvarez-Buylla, E. R. (2020). Multi-level gene regulatory network models to understand complex mechanisms underlying plant development. Current Opinion in Plant Biology, 57, 171-179.
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A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle

Published in PLOS Computational Biology, 2015

This research proposes a Boolean gene regulatory network (GRN) that recovers the robust cyclic behavior of key molecular components in the Arabidopsis thaliana cell cycle.

Recommended citation: Ortiz-Gutiérrez, E., García-Cruz, K., Azpeitia, E., Castillo, A., Sánchez, M. D. L. P., & Álvarez-Buylla, E. R. (2015). A dynamic gene regulatory network model that recovers the cyclic behavior of Arabidopsis thaliana cell cycle. PLoS computational biology, 11(9), e1004486.
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